News

AddToAny

Google+ Facebook Twitter Twitter

Study advances field of precision medicine

A new method of quickly mapping the genome of single cells, while also clarifying the spatial position of the cells within the body, has been revealed.

The discovery represents another milestone in the field of precision medicine, it is claimed.

“It gives us a lot more precision,” said senior author Andrew Adey. 

“The single-cell aspect gives us the ability to track the molecular changes within each cell type. Our new study also allows the capture of where those cells were positioned within complex tissues, as opposed to a slurry of cells from the entire sample.”

Scientists applied a method of indexing large numbers of single cells in hundreds of microbiopsies taken from a portion of the brain in mice and from human brain tissue kept in the Oregon Health and Science University Brain Bank.

Researchers isolated tiny pieces in cross sections of tissues and used an existing technique of single-cell profiling to find differences in the epigenetic profiles of the cells with respect to their position in the tissue.

The technique could be especially useful where it’s necessary to precisely identify and target cells from specific structures within a tissue, such as cancer, or in cases of stroke, which the authors explored in the study.

go.nature.com/3kK0bP8

Image Credit: iStock

Related Articles

Tech news: October

This month's top tech news stories

Under the microscope: chronic allograft dysfunction

What is chronic allograft dysfunction (CLAD)?

A range of pathologies that cause a transplanted lung to not achieve or maintain normal function. CLAD manifests as airflow restriction or obstruction.

Evolutionary changes in brain development

More than 3000 regions in the human genome are very different to those in the genome of any other mammals, including our closest primate relatives.

Turning normal cells into cancer cells

There is new evidence that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients.

Top