News

AddToAny

Google+ Facebook Twitter Twitter

Lung cancers metabolise differently

Researchers have discovered that the two most common forms of lung cancer metabolise nutrients differently, revealing new vulnerabilities that could be exploited in future treatment for patients.

p8-13-lungs-istock-166011791-.jpg

Researchers have discovered that the two most common forms of lung cancer metabolise nutrients differently, revealing new vulnerabilities that could be exploited in future treatment for patients.

When cells become cancerous, they change their metabolism in order to grow rapidly and spread throughout the body. 

Previous studies suggested that the major subtypes of lung cancer differ metabolically, but exactly how they differ was unknown.

In a collaboration led by the Francis Crick Institute and the University of Kentucky, scientists have now worked out how adenocarcinomas and squamous cell carcinomas in human patients metabolise nutrients. These are the two most common forms of lung cancer; around 40% of all lung cancers are adenocarcinomas while 30% are squamous cell carcinomas.

The research reveals that squamous cell carcinomas break down nutrients in a different way to adenocarcinomas and that it is linked to specific genetic events.

Mariia Yuneva, senior study author, said: “Understanding how these cancers process nutrients could help us to develop new targeted treatments and lifestyle interventions. 

“Our findings may also help to explain why these cancers respond to existing treatments in different ways.”`

 

Image credit | iStock

Related Articles

"Disasters lead to reductions in cancer screening"

Cervical cancer screening rates in Japan were significantly affected in the years following the devastating Great East Japan Earthquake of 2011.

Cervical screening in Moldova

Lead Biomedical Scientist and British Association for Cytopathology Executive Committee Member Hedley Glencross introduces a project to improve the outdated cervical screening programme in the Republic of Moldova.

Breakthrough for the leading cause of blindness

Professor Simon Clark discusses how his international team of scientists identified a protein that is strongly linked to the most common cause of blindness in developed countries.

IBMS President inaugurated

Allan Wilson has been inaugurated as the new President of the IBMS.

Top