Google+ Facebook Twitter Twitter

Faecal microbiota transplant for C. diff

In the first comprehensive US evidence-based guideline on the use of faecal microbiota-based therapies for gastrointestinal disease, the American Gastroenterological Association recommends faecal microbiota transplant (FMT) for most patients with recurrent Clostridioides difficile (C. diff) infection.

clostridioides difficile bacteria-Image Credit | Science Photo Library - c0016337

“Using faecal microbiota transplant, we take a stool from a healthy donor and transfer it to the colon of the person with recurrent C. diff, restoring balance to their gut microbiome,” said author Dr Anne Peery.

“FMT is a safe and effective treatment with enough scientific evidence to be offered to most patients with two or more C. diff recurrences.” 

In the US, nearly half a million people each year experience C. diff. One in six of those people will deal with a C. diff recurrence within two to eight weeks. 

For patients with recurrent C. diff infection at a high risk of recurrence, the AGA recommends the use of FMT-based therapy after completing a course of antibiotics. Only severely immunocompromised patients (such as neutropenic patients or those who have received a bone marrow transplant) are excluded from the recommendation.

For hospitalised patients with severe C. diff infection, the AGA recommends the use of conventional FMT following standard-of-care antibiotic therapy in select patients if there is no improvement.

FMT therapies are not recommended as a treatment for inflammatory bowel diseases or irritable bowel syndrome.

Image Credit | Science Photo Library

Related Articles

actinomyces viscosus bacteria CREDIT - science photolibrary

UK standards for microbiology investigations

Chris Ward, IBMS Head of Examinations, and Ruhi Siddiqui, Head of the Standards Unit at the UK Health Security Agency, with the latest updates.


How do viruses jump between hosts?

Cedric Tan, a computational biologist specialising in microbial (meta)genomics, discusses his recent viral genomes study.


Tech round up

Best new tech this month

AI Artificial Intelligence Security Sentinel Password Cyber Security Ransomware Email Phishing Encrypted Technology, Digital Information Protected Secured Lock-CREDIT_istock-1998660059

AI can detect COVID-19 in lung ultrasound images

Artificial intelligence can spot COVID-19 in lung ultrasound images, much like facial recognition software can spot a face in a crowd, new research shows.