Google+ Facebook Twitter Twitter

Preventing allergic reactions

Researchers have discovered a new mechanism in which an antibody can prevent allergic reactions in a broad range of patients.

The team at the Aarhus University in Denmark was intending to find new methods to improve existing treatment for allergies, but instead came across an antibody that apparently operates
in a unique way to block the immune effect and inactivate the allergic process when it is triggered.

The antibody interacts in a complex biochemical process in the human body and prevents the human allergy antibody (IgE) from attaching to cells, so stopping any allergic symptoms.

Edzard Spillner, one of the study authors, said: “We can now describe the interaction of this antibody with its target and the conformational changes very accurately. 

“This allows us to understand how it interferes with the IgE and its specific receptors on the immune cells of the body, which are responsible for releasing histamine in an allergic reaction.” 

A complete paper on the work was published online in January by the journal Nature Communication.

Related Articles

The new dawn of immunotherapy

Steven Rosenberg made headlines around the globe for a breakthrough that could make immunotherapy a frontline cancer treatment.

Vaccine to treat lung cancer

A first-of-its-kind treatment vaccine has moved into a phase I clinical trial for patients with non-small cell lung cancer.

Journal-based learning: iStock

July: Journal-based learning

Each article’s contents should be read, researched and understood, and you should then come to a decision on each question. The pass mark is 17 out of 20 questions answered correctly. JBL exercises may be completed at any time until the published deadline date. Please select your choice of correct answers and complete the exercises online at:

Could bacteriophages replace antibiotics?

A small-scale preliminary trial concludes that bacteriophages could be a viable replacement for antibiotics in the future.