News

AddToAny

Google+ Facebook Twitter Twitter

Molecular mechanisms of parkinson's

Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson’s disease.

For years, scientists have known that Parkinson’s is associated with a build-up of alpha-synuclein protein inside brain cells. But how these protein clumps cause neurons to die was a mystery.

Using a combination of cellular and molecular approaches to compare healthy and clumped forms of alpha-synuclein, a team led by scientists at the Francis Crick Institute, found that clumps of alpha-synuclein damaged key proteins on the surface of mitochondria, making them less efficient at producing energy.

They also triggered a channel on the surface of mitochondria to open, leaking out chemicals that tell the cell to die.

go.nature.com/2JZfrI1

Related Articles

Changes ahead

Role development, workforce strategies and professional qualifications... Sarah May looks back at 2019 and forward to the New Year. 

sarah_may_bw_0_1.jpg

Efficient regulation

A more consistent and transparent regulatory system can only be for the good, writes Sarah May.  

p8-11-news-lego-blocks-istock-459012875.jpg

Imaging with LEGO

Researchers have come up with an inexpensive, automated way to image biological samples – using the children’s toy, LEGO.

megan-clarke-and-team_edit.jpg

My Lab: dynamic histopathology service

Trainee Specialist Biomedical Scientist Megan Clarkson gives a guided tour of her laboratory at Salford Royal NHS Foundation Trust.

Top