News

AddToAny

Google+ Facebook Twitter Twitter

Maturation of human sperm

New research sheds light on the complex process that occurs in the development of human sperm stem cells.

This is the first study to characterise the changes human sperm stem cells undergo as they mature. 

The authors claim the results, published in Cell, have implications for understanding male infertility, as well as cancer development. Previous studies of sperm stem cells have been limited to model systems. 

This first study of developing human sperm stem cells revealed the process is much more complex in humans than had been previously understood. 

The scientists used genome analysis tools to outline the multistage process that sperm stem cells undergo during their normal development.

The study examined all of the genes that turn “on” or “off” in any given cell during normal development. 

Using single cell RNA sequencing analysis, they profiled cells individually, establishing the gene expression profile in human sperm stem cells.

Their findings outline four distinct cellular phases of sperm stem cells maturation, revealing how the stem cells progress from a “quiescent” state, to a “proliferation” state during which stem cells divide, to a final “differentiation” state when stem cells mature to become sperm. 

bit.ly/NovNews5

Related Articles

Consolidation of pathology networks

Head of Pathology Services Consolidation at NHS Improvement, David Wells, sets out the progress made on the 29 networks and looks at the next steps and future plans.
 

Vibrio Cholerae and Flagella Science photo

How to stop cholera

Stopping cholera spreading between members of the same household could be key to reducing cases.

Biomarker Monitoring by Particle Mobility Sensing bpm-cicms Animation Studio

Monitoring biomarkers live

A new technique has been developed that may be the solution for the live monitoring of biomarkers.

hires_img_9924.jpg

My lab: laboratory on the rock

IBMS Gibraltar Branch Secretary Norbert Sene gives a guided tour of the Pathology Department at Saint Bernard’s Hospital in Gibraltar. 

Top