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Mapping the entire human gut at single cell resolution

For the first time, entire human GI tracts from three organ donors have been used to show how cell types differ across all regions of the intestines.

Scientists from the University of North Carolina hope their work will shed light on cellular functions and show gene expression differences between these cells and individuals.

The work opens the door to exploring the many facets of gut health in a much more precise manner at greater resolution than ever before.

Research lead Scott Magness said: “Our lab showed it’s possible to learn about each cell type’s function in important processes, such as nutrient absorption, protection from parasites, and the production of mucus and hormones that regulate eating behaviour and gut motility.

“We also learned how the gut lining might interact with the environment through receptors and sensors and how drugs could interact with different cell types.”

Image credit | Magness Lab UNC School Of Medicine

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