News

AddToAny

Google+ Facebook Twitter Twitter

Improving drug delivery

A group of US scientists has developed a new way to deliver molecules that target specific genes within cells.

Their platform, which uses a modified form of diphtheria toxin, has been shown to down-regulate critical genes in cancer cells, and could be used for other genetic diseases as well.

The team, led by professors Molly Shoichet and Roman Melnyk of SickKids Hospital, found inspiration from an unexpected source – diphtheria toxin.

Shoichet, said: “A major challenge in the field of drug delivery is most therapeutic vehicles cannot escape the acid environment of the endosome once they get into the cell.

“The diphtheria toxin platform as a delivery vehicle effectively solves that.”

The researchers used the system to deliver molecules that they believed would be effective against glioblastoma.  

bit.ly/3cBAr2e

 

Picture Credit | iStock

Related Articles

British Journal of Biomedical Science: Issue 3 2020 - a synopsis

Deputy Editor Guy Orchard provides a brief glimpse of the articles on offer in the third issue of the year.

Blood test for Alzheimer's

A blood test could spot Alzheimer’s disease at the earliest stage and years before symptoms appear, new studies indicate.

The organisation that delivers

After years of frustration, people are finally starting to understand the value of biomedical scientists.

Molecule to remodel microbiome

Scientists at Scripps Research claim they have developed molecules that can remodel the bacterial population of intestines to a healthier state.

Top