News

AddToAny

Google+ Facebook Twitter Twitter

Biomarker for genome instability

Elevated levels of a protein called ubiquilin-4 can be a biomarker for genome instability, a Tel Aviv University study shows.

The researchers found that ubiquilin-4 takes part in defending the genome from DNA damage, but too much of the protein is harmful.

When the amount of ubiquilin-4 in tumour cells rises, the cells become more prone to genome instability, accelerating the tumour’s progression and making it resistant to commonly used cancer treatments.

Professor Yossi Shiloh, who led the study, said: “This novel biomarker provides new, critical information about the tumour stage and grade, as well as the patient’s chances of responding to treatment.

“Tumours with high levels of ubiquilin-4 may be more resistant to radiation and some chemotherapies than those with normal levels of this protein. “But the good news is that they may also respond better to other types of cancer therapy.”

 

Related Articles

Breath testing for gut disorders

Small children may one day avoid invasive oesophageal tube-testing for gut damage and coeliac disease thanks to a new method. It involves blowing into a glass tube to provide effective diagnoses.

p38-39-leadership-woman-shadow-as-a-super-hero-istock-921297240c.jpg

How to… embrace leadership

Clinical Scientist and Molecular Pathology Lead Siobhan Taylor discusses applying for a leadership programme and the benefits it has brought.

p28-29-cholesterol-in-artery-science-photo-library-f0235128.jpg

Approaches to lipid therapy

Consultant Chemical Pathologist Professor Tim Reynolds outlines drug developments over recent decades in lipid therapy.

p16-17-one-to-one-gene-editing-science-photo-library-c0404055.jpg

molecular scissors

Jennifer Doudna is behind a pioneering gene editing technique, potential applications of which range from curing genetic diseases, to improving crops. She discusses the practical and ethical issues. 

Top