News

AddToAny

Google+ Facebook Twitter Twitter

3D model of human liver

Non-alcoholic fatty liver disease is becoming the most common chronic liver disorder in developed countries.

Histological analysis of liver tissue is the only widely accepted test for diagnosing and distinguishing different stages of the disease.

However, this technique provides only two-dimensional images of the liver tissue in low resolution and overlooks potentially important 3D structural changes.

Scientists have now generated 3D geometrical and functional models of human liver tissue for different disease stages. They reveal new critical tissue alterations, providing new insights into pathophysiology and contributing to high-definition medical diagnosis.

Conventional histological analysis of liver tissue is the gold standard for diagnosing disease progression, but it has several potential disadvantages: the low-resolution 2D images of liver tissue may only allow a semi-quantitative evaluation and it can be subjective, since it depends on interpretation.  

go.nature.com/2t42Dco

Image credit | Shutterstock

Related Articles

Reporting in histopathology: some personal insights

The team at Leicester Royal Infirmary have collaborated on this article, which discusses their experiences of scientist reporting in histopathology.

"Don't delay cancer treatment"

A European Society for Medical Oncology (ESMO) interdisciplinary expert consensus paper on how to manage cancer patients during the COVID-19 pandemic has been published.

"AI research could pose risk for patients"

Many studies claiming that artificial intelligence (AI) is as good as, or better than, human experts at interpreting medical images are of poor quality and potentially exaggerated.

Morphology: is the future digital?

Biomedical Scientist Team Manager Tahmina Hussain puts a new automated digital analyser to the test.

Top