News

AddToAny

Google+ Facebook Twitter Twitter

“Rare cells capable of transforming into blood cancer”

Dysfunction involving an unusual type of thymocyte cell found in small amounts in every person may be the reason why some people develop a form of leukaemia called T-cell acute lymphoblastic leukaemia (T-ALL), it is claimed.

Researchers from the University of Missouri characterised the thymocyte cells – an immune cell present in the thymus – while studying mice with T-ALL.

They determined all of the rodent tumours originated from the same type of T cell that expresses a unique set of molecular markers.

Adam Schrum, Associate Professor of Bioengineering, Molecular Microbiology and Immunology, and Surgery, said: “Once we identified the cell in mice, we wondered if humans have that same cell type and in the same quantity. The human samples we obtained contained the same T cells and in the exact quantity found in mice.”

That rare cell, which makes up 0.01% of cells in the thymus gland, became known as EADN.

Over three years, the team examined five T-ALL cases. They found one of the cases seems to have originated from an EADN cell.

Schrum concluded: “We’re not saying that EADN is the only cell that causes this type of cancer, but our findings show it is responsible for some cases. This is a very exciting discovery.”

bit.ly/3Nqcnkv

Image credit | Science-Photo-Library

Related Articles

Antibiotic resistance genes identified in TB

An analysis of more than 10,000 Mycobacterium tuberculosis bacterial isolates from 23 countries has revealed new genes associated with resistance to 13 first- and second-line new and repurposed antibiotics.

A nasal vaccine

Researchers have found the first non-infectious needle-free nasal vaccine to be effective against COVID-19. Senior study co-author Dr Venigalla B Rao explains how it works.

Non-COVID-19 respiratory infections statistics

An increase in the number of non-COVID-19 respiratory infections should be expected this winter, say scientists.

My lab: From flu to Covid to monkeypox

Panagiotis Pantelidis gives a guided tour of Infection and Immunity Sciences at North West London Pathology.

Top