News

AddToAny

Google+ Facebook Twitter Twitter

Molecular mechanisms of parkinson's

Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson’s disease.

For years, scientists have known that Parkinson’s is associated with a build-up of alpha-synuclein protein inside brain cells. But how these protein clumps cause neurons to die was a mystery.

Using a combination of cellular and molecular approaches to compare healthy and clumped forms of alpha-synuclein, a team led by scientists at the Francis Crick Institute, found that clumps of alpha-synuclein damaged key proteins on the surface of mitochondria, making them less efficient at producing energy.

They also triggered a channel on the surface of mitochondria to open, leaking out chemicals that tell the cell to die.

go.nature.com/2JZfrI1

Related Articles

The progress of histopathology reporting

Jo Horne, Andrew Usher and Gerry van Schalkwyk discuss the progress of the histopathology reporting programme and look to the future.

MRI for prostate cancer screening?

MRI for prostate cancer screening?

A new clinical study will test for the first time if MRI scans can be used for population screening to detect prostate cancer more accurately.

"Cancer survivors have increased risk"

Survivors of childhood cancer are at increased risk of suffering prematurely from cardiovascular disease in adulthood, says a new study.

ruth riisnaes lab

My lab: the cancer biomarkers team

Ruth Riisnaes gives a guided tour of her lab at the Institute of Cancer Research in Sutton.

Top