News

AddToAny

Google+ Facebook Twitter Twitter

Maturation of human sperm

New research sheds light on the complex process that occurs in the development of human sperm stem cells.

This is the first study to characterise the changes human sperm stem cells undergo as they mature. 

The authors claim the results, published in Cell, have implications for understanding male infertility, as well as cancer development. Previous studies of sperm stem cells have been limited to model systems. 

This first study of developing human sperm stem cells revealed the process is much more complex in humans than had been previously understood. 

The scientists used genome analysis tools to outline the multistage process that sperm stem cells undergo during their normal development.

The study examined all of the genes that turn “on” or “off” in any given cell during normal development. 

Using single cell RNA sequencing analysis, they profiled cells individually, establishing the gene expression profile in human sperm stem cells.

Their findings outline four distinct cellular phases of sperm stem cells maturation, revealing how the stem cells progress from a “quiescent” state, to a “proliferation” state during which stem cells divide, to a final “differentiation” state when stem cells mature to become sperm. 

bit.ly/NovNews5

Related Articles

Growing brains

Growing brains

They may only be small collections of cells at present, but neurological surgeon Ben Waldau believes that brain organoids could have a big impact in the future.

100,000 Genomes Project hits halfway

100,000 Genomes Project hits halfway

Genomics England has passed the halfway point in its mission to sequence 100,000 genomes.

The genetic basis of Alzheimer's

After he was awarded another illustrious prize for his Alzheimer’s disease research, we speak to Professor John Hardy about his work.

Molecular printing advance

A new fabrication technology could allow researchers to recreate complex biological environments.

Top